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KMID : 0606920070150010007
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Biomolecules & Therapeutics
2007 Volume.15 No. 1 p.7 ~ p.15
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Molecular Events on Experimental Skin Inflammation and Modulation by Topical Anti-inflammatory Flavonoids
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Kim Hyun-Pyo
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Abstract
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There have been various animal models of skin inflammation. These models have been used for establishing anti-inflammatory activity of the topical agents including cosmetics. Here, the molecular mechanisms of most widely-used animal models of skin inflammation including contact irritation, acute and chronic inflammation, and delayed-type hypersensitivity are summarized. Against these animal models, varieties of plant flavonoids showed anti-inflammatory activity. The action mechanisms of anti-inflammation by topical flavonoids are presented. A therapeutic potential of flavonoids is discussed.
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KEYWORD
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skin, inflammation, flavonoid
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